Strain Data Sheet

RBRC01732

Strain Information

Image
BRC No.RBRC01732
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Sorbs3<tm1Kmor>/Rbrc
Former Common nameVinexinKO/C57B6
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Noriyuki Kioka, Kyoto University in 2001.
Strain descriptionB6.Cg-Sorbs3<tm>. Sorbs3 (Vinexein) gene is a cytoskeletal protein that plays a key role in the regulation of cytoskeletal organization and signal transduction. This strain is useful for elucidation of the role of the functions of this gene.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc)
References
Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface.
Mitsushima M, Ueda K, Kioka N
Genes Cells, 11, 971-982 (2006). 16923119

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sorbs3
MGI:700013		sorbin and SH3 domain containing 314Sorbs3<tm1Kmor>
MGI:3611214		targeted mutation 1, Ken-ichirou Morohashi
neo neomycin resistance gene (E. coli)14 polyoma virus thymidine kinase gene promoter (tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cell migration(MP:0003091)

  • delayed wound healing(MP:0002908)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMC1neo (polyoma virus thymidine kinase gene promoter and E. coli neomycin resistance gene) (Developmental Biology, 194, 152-165); mouse vinexin genomic DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorNoriyuki Kioka (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H.
    Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
    J Neurochem 134(2) 211-21(2015) 25824575