Strain Data Sheet

RBRC01945

Strain Information

Image
BRC No.RBRC01945
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Mesp2<tm12Ysa>/Rbrc
Former Common nameP2Em B1D, P2EmB1D enhancer knockout mouse
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2.
Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, Saga Y
Development., 135, 3511-3519 (2008). 18849530

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mesp2
MGI:1096325		mesoderm posterior 27Mesp2<tm12Ysa>
MGI:3817238		targeted mutation 12, Yukimo Saga
  • spondylocostal dysostosis 1, autosomal recessive(MedGEN)

  • spondylocostal dysostosis 2, autosomal recessive(MedGEN)
    • neo neomycin resistance gene (E. coli)7

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal skeleton morphology(MP:0005508)

  • abnormal vertebrae morphology(MP:0000137)

  • perinatal lethality(MP:0002081)

  • rib fusion(MP:0000154)

  • short vertebral column(MP:0004704)
    • Detailed phenotype data

    Ordering Information

    Donor DNA大腸菌由来ネオマイシン耐性遺伝子
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development. 135, 3511-3519 (2008 ).
    DepositorJun Kanno (National Institute of Health Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data