Strain Data Sheet

RBRC02092

Strain Information

Image
BRC No.RBRC02092
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Omp<tm3Mom>/MomTyagRbrc
Former Common nameOMP-GFP
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Peter Mombaerts, The Rockefeller University in 2001.
Strain descriptionOMP (olfactory marker protein) gene GFP knock-in mice. The GFP/LTNL cassette was inserted into the Omp gene. Homozygous mutant mice are viable and fertile.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6J(Crlj)]
References
Structure and emergence of specific olfactory glomeruli in the mouse.
Potter S M, Zheng C, Koos D S, Feinstein P, Fraser S E, Mombaerts P
J. Neurosci., 21, 9713-9723 (2001). 11739580

The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.
Hasegawa S, Hamada S, Kumode Y, Esumi S, Katori S, Fukuda E, Uchiyama Y, Hirabayashi T, Mombaerts P, Yagi T
Mol Cell Neurosci, 38, 66-79 (2008). 18353676

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFP Green Fluorescent Protein (Aequorea victoria)7
Omp
MGI:97436		olfactory marker protein7Omp<tm3Mom>
MGI:3692201		targeted mutation 3, Peter Mombaerts
loxP phage P1 loxP7loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAJellyfish GFP cDNA, Phage P1 loxP site, mouse Omp genomic DNA
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Neurobiology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior consent on use of it from Professor Peter Monbaerts, The Rockefeller University. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate the treatment of such invention. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR. The RECIPIENT, which wishes to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research, is requested to enter into a Material Transfer Agreement with Osaka University.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese), Co-creation Bureau, Osaka University HP

    BRC mice in Publications

    Nakashima N, Nakashima K, Takaku-Nakashima A, Takano M.
    Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus.
    Mol Brain 12(1) 54(2019) 31164142