Strain Data Sheet

RBRC02106

Strain Information

Image
BRC No.RBRC02106
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Lefty1<tm1Hmd>
Former Common namelefty 1 null KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.
Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H
Cell, 94, 287-297 (1998). 9708731

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Lefty1
MGI:107405
left right determination factor 11Lefty1<tm1Hmd>
MGI:2179534
targeted mutation 1, Hiroshi Hamada
neo neomycin resistance gene (E. coli)1 SV40 and herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal azygos vein morphology(MP:0011569)

  • abnormal bronchus morphology(MP:0002264)

  • abnormal cardiac outflow tract development(MP:0006126)

  • abnormal heart and great vessel attachment(MP:0010425)

  • abnormal heart morphology(MP:0000266)
  • more 19 phenotypes
  • abnormal heart position or orientation(MP:0006065)

  • abnormal hepatic portal vein morphology(MP:0010668)

  • abnormal inferior vena cava morphology(MP:0006063)

  • abnormal left renal vein morphology(MP:0011327)

  • abnormal liver morphology(MP:0000598)

  • abnormal vein morphology(MP:0002725)

  • atrial septal defect(MP:0010403)

  • complete atrioventricular septal defect(MP:0010413)

  • double outlet right ventricle(MP:0000284)

  • embryonic lethality during organogenesis, incomplete penetrance(MP:0011108)

  • left atrial isomerism(MP:0008461)

  • left pulmonary isomerism(MP:0003178)

  • left-sided isomerism(MP:0000542)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • right aortic arch(MP:0004158)

  • situs inversus(MP:0002766)

  • transposition of great arteries(MP:0004110)

  • tricuspid valve atresia(MP:0006123)

  • ventricular septal defect(MP:0010402)
  • Detailed phenotype data

    Ordering Information

    Donor DNASV40 初期遺伝子プロモーター, HSV チミジンキナーゼ遺伝子プロモーター, E. coli 由来ネオマイシン耐性遺伝子, SV40Ter 遺伝子のpolyA 付加シグナル
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 94, 287-297 (1998).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Mouse of the Month May 2007

    BRC mice in Publications

    No Data