Strain Data Sheet

RBRC02107

Strain Information

Image
BRC No.RBRC02107
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Nodal<tm1Hmd>
Former Common namenodal<LSEneo>
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Left-right patterning of the mouse lateral plate requires nodal produced in the node.
Saijoh Y, Oki S, Ohishi S, Hamada H
Dev. Biol., 256,160-72 (2003). 12654299

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Nodal
MGI:97359
nodal growth differentiation factor10Nodal<tm1Hmd>
MGI:2654943
targeted mutation 1, Hiroshi Hamada
loxP phage P1 loxP10loxP
loxP phage P1 loxP10loxP
neo neomycin resistance gene (E. coli)10

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cardiac outflow tract development(MP:0006126)

  • abnormal digestive system development(MP:0003119)

  • abnormal heart position or orientation(MP:0006065)

  • abnormal left-right axis patterning(MP:0001706)

  • abnormal liver morphology(MP:0000598)
  • more 12 phenotypes
  • abnormal spleen morphology(MP:0000689)

  • abnormal stomach position or orientation(MP:0010807)

  • dextrocardia(MP:0000644)

  • embryonic growth arrest(MP:0001730)

  • embryonic lethality during organogenesis, incomplete penetrance(MP:0011108)

  • perinatal lethality, complete penetrance(MP:0011089)

  • right atrial isomerism(MP:0006061)

  • right pulmonary isomerism(MP:0000531)

  • right-sided isomerism(MP:0000508)

  • small spleen(MP:0000692)

  • spleen hypoplasia(MP:0000694)

  • transposition of great arteries(MP:0004110)
  • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli 由来 neo 遺伝子, マウス由来 pgk プロモーター, phage P1 loxP
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 256,160-72 (2003).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Mouse of the Month May 2007

    BRC mice in Publications

    No Data