Strain Data Sheet
RBRC02147
Strain Information | |
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| Image | |
| BRC No. | RBRC02147 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | STOCK Pcdha<tm3Tyag> Olfr160<tm6Mom>/TyagRbrc |
| Former Common name | M72-GFP/CNR BdAB |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Developed by Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University. The mutant mice were generated by crossing with CNR delta CR (BdAB) (RBRC01688) (Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University) and M72-GFP mice (Peter Monbaerts, The Rockefeller University). |
| Strain description | CNR (Pcdha) delta CR mutant and M72 (Olfr160) gene ires-tauGFP knock-in double mutant mice. |
| Colony maintenance | Pcdha: Homozygote x Homozygote; Olfr160: Homozygote x Homozygote |
| References | Structure and emergence of specific olfactory glomeruli in the mouse. Potter S M, Zheng C, Koos D S, Feinstein P, Fraser S E, Mombaerts P J. Neurosci., 21, 9713-9723 (2001). 11739580The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. Hasegawa S, Hamada S, Kumode Y, Esumi S, Katori S, Fukuda E, Uchiyama Y, Hirabayashi T, Mombaerts P, Yagi T Mol Cell Neurosci, 38, 66-79 (2008). 18353676 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Pcdha MGI:3719085 | protocadherin alpha cluster | 18 | Pcdha<tm3Tyag> MGI:3797610 | targeted mutation 3, Takeshi Yagi | |||
| loxP | phage P1 loxP | 18 | loxP | ||||
| GFP | Green Fluorescent Protein (Aequorea victoria) | 9 | |||||
| IRES | internal ribosomal entry site (EMCV) | 9 | |||||
| Olfr160 MGI:1931271 | olfactory receptor 160 | 9 | Olfr160<tm6Mom> MGI:3692202 | targeted mutation 6, Peter Mombaerts | |||
| loxP | phage P1 loxP | 9 | loxP | ||||
| neo | neomycin resistance gene (E. coli) | 9 | |||||
| tau | bovine tau protein cDNA | 9 | tau | ||||
Phenotype | |
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| Phenotype annotation from literatures by Mammalian phenotype ontology | more 15 phenotypes |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | Phage P1 loxP, Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires),bovine tau cDNA, mouse Olfr160 genomic DNA, mouse Pcdha genomic DNA, Jellyfish GFP cDNA |
| Research application | Cre/loxP system Fluorescent Proteins/lacZ System Neurobiology Research |
| Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior consent on use of it from Professor Peter Monbaerts, The Rockefeller University. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate the treatment of such invention. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR. The RECIPIENT, which wishes to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research, is requested to enter into a Material Transfer Agreement with Osaka University. |
| Depositor | Takeshi Yagi (Osaka University) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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| No Data |