Strain Data Sheet

RBRC02187

Strain Information

Image
BRC No.RBRC02187
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSmt
Former Common name
H-2 Haplotype
ES Cell line
Background strainSmt (C57BL/6, DDK, CBA)
Appearancealbino [A/A B/B c/c]
agouti [A/A B/B C/c]
Strain developmentDeveloped by Drs. Noboru Wakasugi and Hasbaira Bolor at Nagoya University in 1997-2007.
Strain descriptionSpontaneous mutant strain having small testes. Mixed background (C57BL/6=10.9%, DDK=76.6%, CBA=12.5%)
Colony maintenanceSibling Mating (Homozyous, Heterozygous female x Heterozygous male, albino x agouti)
References
Arrest of spermatogenesis at the early meiotic stage in the small testis mutant (Smt) mice.
Bolor H, Zhao W D, Ishikawa A, Wakasugi N
Exp. Anim., 54, 327-337 (2005). 16093646

Detection of quantitative trait loci causing abnormal spermatogenesis and reduced testis weight in the small testis (Smt) mutant mouse.
Bolor H, Wakasugi N, Zhao W D, Ishikawa A
Exp. Anim., 55, 97-108 (2006). 16651692

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
smt small testissmt

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal male meiosis (MP:0005169)

  • abnormal sperm number (MP:0002673)

  • abnormal spermatid morphology (MP:0006380)

  • abnormal spermatocyte morphology (MP:0006379)

  • abnormal spermatogenesis (MP:0001156)
    • more 3 phenotypes
  • failure of zygotic cell division (MP:0003406)

  • seminiferous tubule degeneration (MP:0001154)

  • small testis (MP:0001147)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationReproductive Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Exp. Anim., 54, 327-337 (2005).
    DepositorTakao Namikawa (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data