Strain Data Sheet

RBRC02296

Strain Information

Image
BRC No.RBRC02296
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameBDF1-Tg(Crx-Gatad1)1Homy
Former Common nameBDF1-Tg(Crx-ODAG)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice.
Sasaki T, Watanabe W, Muranishi Y, Kanamoto T, Aihara M, Miyazaki K, Tamura H, Saeki T, Oda H, Souchelnytskyi N, Souchelnytskyi S, Aoyama H, Honda Z, Furukawa T, Mishima H K, Kiuchi Y, Honda H
Invest Ophthalmol Vis Sci., 50(1):242-8 (2009). 18791169

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFPGreen Fluorescent Protein (Aequorea victoria)UN
  • cone-rod dystrophy 2(DisGeNET, MedGEN)

  • dilated cardiomyopathy 2B(MedGEN)

  • Leber congenital amaurosis 7(DisGeNET, MedGEN)
  • more 2 Diseases
  • Leber congenital amaurosis(DisGeNET)

  • retinitis pigmentosa(DisGeNET, MedGEN)
  • Gatad1GATA zinc finger domain containing 1UNGatad1Crx (cone-rod homeobox containing gene) promoter
  • cone-rod dystrophy 2(DisGeNET, MedGEN)

  • dilated cardiomyopathy 2B(MedGEN)

  • Leber congenital amaurosis 7(DisGeNET, MedGEN)
  • more 2 Diseases
  • Leber congenital amaurosis(DisGeNET)

  • retinitis pigmentosa(DisGeNET, MedGEN)
  • IRESinternal ribosomal entry site (EMCV)UN
  • cone-rod dystrophy 2(DisGeNET, MedGEN)

  • dilated cardiomyopathy 2B(MedGEN)

  • Leber congenital amaurosis 7(DisGeNET, MedGEN)
  • more 2 Diseases
  • Leber congenital amaurosis(DisGeNET)

  • retinitis pigmentosa(DisGeNET, MedGEN)
  • poly ASV40 polyA signalUNpoly A
  • cone-rod dystrophy 2(DisGeNET, MedGEN)

  • dilated cardiomyopathy 2B(MedGEN)

  • Leber congenital amaurosis 7(DisGeNET, MedGEN)
  • more 2 Diseases
  • Leber congenital amaurosis(DisGeNET)

  • retinitis pigmentosa(DisGeNET, MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal cornea morphology(MP:0001312)

  • abnormal intraocular pressure(MP:0005257)

  • abnormal iridocorneal angle(MP:0004221)

  • abnormal retina development(MP:0009772)

  • abnormal retina progenitor cell morphology(MP:0006071)
  • more 8 phenotypes
  • absent optic disk(MP:0011389)

  • buphthalmos(MP:0009274)

  • cornea opacity(MP:0001314)

  • cornea vascularization(MP:0005542)

  • exophthalmos(MP:0002750)

  • optic nerve compression(MP:0006220)

  • small optic nerve(MP:0020342)

  • thin retina ganglion layer(MP:0008507)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse crx genomic DNA, mouse Gatad1 cDNA, Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires), Jellyfish GFP cDNA, SV40 virus polyA signal
    Research applicationFluorescent Proteins/lacZ System
    Sensorineural Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHiroaki Honda (Tokyo Women's Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data