Strain Data Sheet

RBRC02327

Strain Information

Image
BRC No.RBRC02327
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameNOD.129P2(B6)-Fcer1g<tm1Rav>
Former Common nameNOD.γ-/-
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainNOD/ShiJcl
Appearance
Strain development
Strain description
Colony maintenance
References
FcR gamma chain deletion results in pleiotrophic effector cell defects.
Takai T, Li M, Sylvestre D, Clynes R, Ravetch J V
Cell, 76(3):519-29 (1994). 8313472

Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice.
Inoue Y, Kaifu T, Sugahara-Tobinai A, Nakamura A, Miyazaki J, Takai T
J. Immunol., 179, 764-774 (2007). 17617565

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fcer1g
MGI:95496		Fc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>
MGI:1857165		targeted mutation 1, Jeffrey V Ravetch
neo neomycin resistance gene (E. coli)1 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal NK cell physiology(MP:0010766)

  • abnormal dendritic cell antigen presentation(MP:0002455)

  • abnormal hemoglobin(MP:0001588)

  • abnormal immune cell physiology(MP:0001819)

  • abnormal immunoglobulin level(MP:0002490)
    • more 19 phenotypes
  • abnormal mast cell physiology(MP:0002423)

  • abnormal platelet activation(MP:0006298)

  • decreased interleukin-1 beta secretion(MP:0008658)

  • decreased interleukin-10 secretion(MP:0008661)

  • decreased interleukin-12b secretion(MP:0008670)

  • decreased interleukin-23 secretion(MP:0008691)

  • decreased interleukin-6 secretion(MP:0008706)

  • decreased myocardial infarct size(MP:0003038)

  • decreased platelet aggregation(MP:0009549)

  • decreased platelet calcium level(MP:0004867)

  • decreased susceptibility to experimental autoimmune encephalomyelitis(MP:0004800)

  • decreased susceptibility to type I hypersensitivity reaction(MP:0005597)

  • decreased tumor necrosis factor secretion(MP:0008561)

  • hematoma(MP:0008817)

  • immune system phenotype(MP:0005387)

  • impaired macrophage phagocytosis(MP:0001798)

  • increased IgE level(MP:0002497)

  • increased susceptibility to parasitic infection(MP:0005027)

  • skeleton phenotype(MP:0005390)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse fcer1g genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007).
    DepositorToshiyuki Takai (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Zhang G, Bogdanova N, Gao T, Sheikh KA.
    Elimination of activating Fcγ receptors in spontaneous autoimmune peripheral polyneuropathy model protects from neuropathic disease.
    PLoS One 14(8) e0220250(2019) 31415574