Strain Information | |
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Image | |
BRC No. | RBRC02330 |
Type | Targeted Mutation Congenic![]() |
Species | Mus musculus |
Strain name | NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk> |
Former Common name | NODFcγRnull |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | albino [A/A c/c] |
Strain development | Developed by Drs. Y. Inoue and T. Takai, Tohoku University in 2004. |
Strain description | FcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background. |
Colony maintenance | Sibling Mating (Homozygote x Homozygote)This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices. |
References | FcR gamma chain deletion results in pleiotrophic effector cell defects. Takai T, Li M, Sylvestre D, Clynes R, Ravetch J V Cell, 76(3):519-29 (1994). 8313472Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Takai T, Ono M, Hikida M, Ohmori H, Ravetch J V Nature, 379, 346-349 (1996). 8552190Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice. Inoue Y, Kaifu T, Sugahara-Tobinai A, Nakamura A, Miyazaki J, Takai T J. Immunol., 179, 764-774 (2007). 17617565 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Fcer1g MGI:95496 | Fc receptor, IgE, high affinity I, gamma polypeptide | 1 | Fcer1g<tm1Rav> MGI:1857165 | targeted mutation 1, Jeffrey V Ravetch | |||
Fcgr2b MGI:95499 | Fc receptor, IgG, low affinity IIb | 1 | Fcgr2b<tm1Ttk> MGI:1857166 | targeted mutation 1, Toshiyuki Takai | |||
neo | neomycin resistance gene (E. coli) | 1 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
neo | neomycin resistance gene (E. coli) | 1 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 45 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007). |
Depositor | Toshiyuki Takai (Tohoku University) |
Strain Status | ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. NPJ Vaccines 8(1) 106(2023) 37488116 |
Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H. Agonistic anti-CD40 induces thyrocyte proliferation and promotes thyroid autoimmunity by increasing CD40 expression on thyroid epithelial cells. J Immunol 190(8) 3928-38(2013) 23509363 |