Strain Data Sheet

RBRC02335

Strain Information

Image
BRC No.RBRC02335
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Drd5<tm1Mok>
Former Common nameDRD5 dopamine receptpor KO mice
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H, Kodama T, Takada M
PLoS One, 8(10):e75975 (2013). 24155877

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd5
MGI:94927		dopamine receptor D55Drd5<tm1Mok>
MGI:5569103		targeted mutation 1, Motoya Katsuki
  • attention deficit-hyperactivity disorder(MedGEN)

  • benign essential blepharospasm(MedGEN)
    • Ecogpt E.coli xanthine phosphoribosyltransferase5Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
    neo neomycin resistance gene (E. coli)5 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal behavioral response to methamphetamine(MP:0012733)

  • behavior/neurological phenotype(MP:0005386)

  • induced hyperactivity(MP:0008911)

  • nervous system phenotype(MP:0003631)
    • Detailed phenotype data

    Ordering Information

    Donor DNAバクテリア由来のネオマイシン耐性遺伝子、xanthine-guanine phosphorybosyl transferase遺伝子、マウスの3-phosphogrycerate kinase遺伝子
    Research applicationNeurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorMasahiko Takada (Tokyo Metropolitan Institute of Medical Science)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data