Strain Information | |
---|---|
Image | |
BRC No. | RBRC02345 |
Type | Transgene |
Species | Mus musculus |
Strain name | FVB-Tg(NF2d39)27Gth |
Former Common name | P0-Nf2delta2-3(#27)tg |
H-2 Haplotype | |
ES Cell line | |
Background strain | FVB |
Appearance | albino [A/A B/B c/c D/D P/P] |
Strain development | Developed by Dr. Marco Giovannini, INSERM France in 1998. FVB background. |
Strain description | This transgenic mouse expresses mutant human neurofibromatosis 2 gene under the control of the Schwann cell-specific P0 gene promoter. |
Colony maintenance | Sibling Mating (Hemizygote x Wild-type) |
References | Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Giovannini M, Robanus-Maandag E, Niwa-Kawakita M, van der Valk M, Woodruff J M, Goutebroze L, Merel P, Berns A, Thomas G Genes Dev., 13, 978-986 (1999) 10215625 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |||||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
HBB2 | rabbit beta-globin polyA | UN | HBB2 | ||||
Nf2 | neurofibromatosis 2 | UN | Nf2 | rat P0 promoter |
Phenotype | |
---|---|
Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
---|---|
Donor DNA | rat P0 promoter, human NF2 cDNAs encoding isoform 1 of Sch-delta(39-121), rabbit beta-globin polyA |
Research application | Cancer Research Developmental Biology Research Mouse Models for Human Disease Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 13, 978-986 (1999). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use. RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention. In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters. |
Depositor | Marco Giovannini (INSERM) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
Truong K, Ahmad I, Jason Clark J, Seline A, Bertroche T, Mostaert B, Van Daele DJ, Hansen MR. Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury. Neuroscience 374 205-213(2018) 29408605 |