Strain Data Sheet

RBRC02345

Strain Information

Image
BRC No.RBRC02345
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameFVB-Tg(NF2d39)27Gth
Former Common nameP0-Nf2delta2-3(#27)tg
H-2 Haplotype
ES Cell line
Background strainFVB
Appearancealbino [A/A B/B c/c D/D P/P]
Strain developmentDeveloped by Dr. Marco Giovannini, INSERM France in 1998. FVB background.
Strain descriptionThis transgenic mouse expresses mutant human neurofibromatosis 2 gene under the control of the Schwann cell-specific P0 gene promoter.
Colony maintenanceSibling Mating (Hemizygote x Wild-type)
References
Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein.
Giovannini M, Robanus-Maandag E, Niwa-Kawakita M, van der Valk M, Woodruff J M, Goutebroze L, Merel P, Berns A, Thomas G
Genes Dev., 13, 978-986 (1999) 10215625

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HBB2rabbit beta-globin polyAUNHBB2
  • Charcot-Marie-Tooth disease type 1B(DisGeNET, MedGEN)

  • Charcot-Marie-Tooth disease type 3(DisGeNET, MedGEN)

  • Charcot-Marie-Tooth disease dominant intermediate D(MedGEN)
  • more 8 Diseases
  • Charcot-Marie-Tooth disease type 2I(MedGEN)

  • Charcot-Marie-Tooth disease type 2J(MedGEN)

  • familial meningioma(MedGEN)

  • meningioma(DisGeNET)

  • neurofibromatosis type 2(DisGeNET, MedGEN)

  • neuropathy, congenital hypomyelinating, 2(MedGEN)

  • Roussy-Levy syndrome(MedGEN)

  • schwannomatosis 1(MedGEN)
  • Nf2neurofibromatosis 2UNNf2rat P0 promoter
  • Charcot-Marie-Tooth disease type 1B(DisGeNET, MedGEN)

  • Charcot-Marie-Tooth disease type 3(DisGeNET, MedGEN)

  • Charcot-Marie-Tooth disease dominant intermediate D(MedGEN)
  • more 8 Diseases
  • Charcot-Marie-Tooth disease type 2I(MedGEN)

  • Charcot-Marie-Tooth disease type 2J(MedGEN)

  • familial meningioma(MedGEN)

  • meningioma(DisGeNET)

  • neurofibromatosis type 2(DisGeNET, MedGEN)

  • neuropathy, congenital hypomyelinating, 2(MedGEN)

  • Roussy-Levy syndrome(MedGEN)

  • schwannomatosis 1(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
  • Detailed phenotype data

    Ordering Information

    Donor DNArat P0 promoter, human NF2 cDNAs encoding isoform 1 of Sch-delta(39-121), rabbit beta-globin polyA
    Research applicationCancer Research
    Developmental Biology Research
    Mouse Models for Human Disease
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 13, 978-986 (1999). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use.
    RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention.
    In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters.
    DepositorMarco Giovannini (INSERM)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Truong K, Ahmad I, Jason Clark J, Seline A, Bertroche T, Mostaert B, Van Daele DJ, Hansen MR.
    Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury.
    Neuroscience 374 205-213(2018) 29408605