Strain Data Sheet

RBRC02363

Strain Information

Image
BRC No.RBRC02363
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129S2-Pdcd1<tm1Hon>(N20)
Former Common nameBALB/c-Pdcd1<-/-> mouse
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain developmentBackcrossed to BALB/c for 20 generations. Developed by Dr. Tasuku Honjo, Kyoto University.
Strain description
Colony maintenance
References
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.
Nishimura H, Minato N, Nakano T, Honjo T
Int. Immunol., 10, 1563-1572 (1998). 9796923

Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
Nishimura H, Nose M, Hiai H, Minato N, Honjo T
Immunity, 11, 141-151 (1999). 10485649

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T
Science, 291, 319-322 (2001). 11209085

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pdcd1
MGI:104879		programmed cell death 11Pdcd1<tm1Hon>
MGI:2386184		targeted mutation 1, Tasuku Honjo
  • multiple sclerosis, susceptibility to(MedGEN)

  • systemic lupus erythematosus, susceptibility to, 2(MedGEN)
    • neo neomycin resistance gene (E. coli)1 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell activation(MP:0001828)

  • abnormal cardiac muscle contractility(MP:0002972)

  • abnormal cardiac output(MP:0001627)

  • abnormal cardiovascular system physiology(MP:0001544)

  • abnormal heart morphology(MP:0000266)
    • more 29 phenotypes
  • abnormal immunoglobulin level(MP:0002490)

  • abnormal leukopoiesis(MP:0005460)

  • abnormal myelopoiesis(MP:0001601)

  • abnormal response to transplant(MP:0005671)

  • arthritis(MP:0002993)

  • cardiac fibrosis(MP:0003141)

  • decreased susceptibility to experimental autoimmune encephalomyelitis(MP:0004800)

  • dilated heart ventricle(MP:0008022)

  • enlarged heart(MP:0000274)

  • enlarged liver(MP:0000599)

  • enlarged spleen(MP:0000691)

  • exophthalmos(MP:0002750)

  • glomerulonephritis(MP:0002743)

  • hepatic necrosis(MP:0001654)

  • increased B cell number(MP:0005014)

  • increased B cell proliferation(MP:0005154)

  • increased B-1 B cell number(MP:0004977)

  • increased IgA level(MP:0002495)

  • increased IgG2b level(MP:0008501)

  • increased IgG3 level(MP:0008502)

  • increased IgM level(MP:0002494)

  • increased autoantibody level(MP:0003725)

  • increased inflammatory response(MP:0001846)

  • increased interferon-gamma secretion(MP:0008566)

  • increased lymphocyte cell number(MP:0005013)

  • pancreas necrosis(MP:0009148)

  • premature death(MP:0002083)

  • pulmonary necrosis(MP:0010857)

  • thin ventricular wall(MP:0000280)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse PD-1(immunoglobulin superfamily member) genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Science 291, 319-322 (2001).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-
    Mouse of the Month Jul 2012

    BRC mice in Publications

    No Data