Strain Data Sheet

RBRC02365

Strain Information

Image
BRC No.RBRC02365
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Actb-Pdcd1)BHon
Former Common namePD-1-Tg (lineB) (C57BL/6), C57BL/6-Tg(ACTB-Pdcd1)B mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Iwai Y, Terawaki S, Honjo T
Int. Immunol., 17, 133-144 (2005). 15611321

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pdcd1
MGI:104879
programmed cell death 1UNPdcd1 chicken beta-actin promoter
  • multiple sclerosis, susceptibility to(MedGEN)

  • systemic lupus erythematosus, susceptibility to, 2(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal immune system physiology(MP:0001790)

  • increased tumor incidence(MP:0002020)
  • Detailed phenotype data

    Ordering Information

    Donor DNAchicken β-actin promoter, mouse PD-1 cDNA, SV40 polyA
    Research applicationImmunology and Inflammation Research
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Int. Immunol., 17, 133-144 (2005).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP

    BRC mice in Publications

    No Data