Strain Data Sheet

RBRC02373

Strain Information

Image
BRC No.RBRC02373
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-shm/Oda
Former Common nameB6.Cg-shm/Oda
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
A novel Caspr mutation causes the shambling mouse phenotype by disrupting axoglial interactions of myelinated nerves.
Sun X Y, Takagishi Y, Okabe E, Chishima Y, Kanou Y, Murase S, Mizumura K, Inaba M, Komatsu Y, Hayashi Y, Peles E, Oda S, Murata Y
J. Neuropathol. Exp. Neurol., 68(11):1207-18 (2009). 19816196

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cntnap1
MGI:1858201		contactin associated protein-like 111Cntnap1<shm>
MGI:1857037		shambling
  • lethal congenital contracture syndrome 7(MedGEN)

  • neuropathy, congenital hypomyelinating, 3(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal axon morphology (MP:0005404)

  • abnormal gait (MP:0001406)

  • abnormal limb posture (MP:0004263)

  • abnormal motor coordination/balance (MP:0001516)

  • abnormal nerve conduction (MP:0005403)
    • more 16 phenotypes
  • abnormal node of Ranvier morphology (MP:0010732)

  • abnormal paranodal axoglial junction morphology (MP:0010735)

  • abnormal paranode morphology (MP:0010734)

  • abnormal resting posture (MP:0009393)

  • abnormal visual evoked potential (MP:0010748)

  • ataxia (MP:0001393)

  • decreased body size (MP:0001265)

  • decreased locomotor activity (MP:0001402)

  • decreased nerve conduction velocity (MP:0008814)

  • decreased survivor rate (MP:0008770)

  • impaired coordination (MP:0001405)

  • impaired limb coordination (MP:0001524)

  • impaired swimming (MP:0001522)

  • lethality at weaning, complete penetrance (MP:0011083)

  • reduced fertility (MP:0001921)

  • tremors (MP:0000745)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorSenichi Oda (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data