Strain Data Sheet

RBRC02374

Strain Information

Image
BRC No.RBRC02374
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Cav3<tm1Ncnp>/177
Former Common namecav3-KO/B6(177), B6-Cav3 KO#177
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Toshikuni Sasaoka, National Institutes of Natural Sciences (National Institute of Neuroscience, National Center of Neurology and Psychiatry).
Strain descriptionCav3 (Caveolin 3) gene knockout mice. Cav3 is a muscle-specific form of the caveolin family proteins, which are small molecular weight proteins shown to be associated with the caveolar plasma membrane. Homozygous mutant mice show mid myopathic changes in muscle from 8 weeks ages. Viable and fertile. Line 177 (C57BL/6 background) (RBRC02374), Line 32 (mixed background) (RBRC02375), Line 142 (mixed background), Line 177 (mixed background) (RBRC02377).
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Caveolin-3 deficiency causes muscle degeneration in mice.
Hagiwara Y, Sasaoka T, Araishi K, Imamura M, Yorifuji H, Nonaka I, Ozawa E, Kikuchi T
Hum. Mol. Genet., 9(20):3047-3054 (2000). 11115849

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cav3
MGI:107570		caveolin 36Cav3<tm1Ncnp >
MGI:2684578		targeted mutation 1, Tateki Kikuchi
  • creatine phosphokinase, elevated serum(MedGEN)

  • distal myopathy, Tateyama type(MedGEN)

  • hypertrophic cardiomyopathy 1(MedGEN)
    • more 2 Diseases
  • long QT syndrome 9(MedGEN)

  • rippling muscle disease 2(MedGEN)
    • neo neomycin resistance gene (E. coli)6 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal atrium myocardial trabeculae morphology(MP:0010581)

  • abnormal heart atrium morphology(MP:0003105)

  • abnormal muscle development(MP:0000733)

  • abnormal muscle fiber morphology(MP:0004087)

  • abnormal myocardial fiber morphology(MP:0000278)
    • more 3 phenotypes
  • centrally nucleated skeletal muscle fibers(MP:0009404)

  • muscle degeneration(MP:0000749)

  • thick ventricular wall(MP:0002953)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E coli neo, mouse caveolin-3(Cav3) genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 9(20):3047-3054 (2000). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data