Strain Data Sheet

RBRC02377

Strain Information

Image
BRC No.RBRC02377
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4-Cav3<tm1Ncnp>/177
Former Common namecav3-KO/177, Cav3 KO#177
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain developmentDeveloped by Toshikuni Sasaoka, National Institutes of Natural Sciences (National Institute of Neuroscience, National Center of Neurology and Psychiatry).
Strain descriptionCav3 (Caveolin 3) gene knockout mice. Cav3 is a muscle-specific form of the caveolin family proteins, which are small molecular weight proteins shown to be associated with the caveolar plasma membrane. Homozygous mutant mice show mid myopathic changes in muscle from 8 weeks ages. Viable and fertile. Line 177 (C57BL/6 background) (RBRC02374), Line 32 (mixed background) (RBRC02375), Line 142 (mixed background), Line 177 (mixed background) (RBRC02377).
Colony maintenanceHomozygote x Heterozygote [or Crossing to C57BL/6JJcl]
References
Caveolin-3 deficiency causes muscle degeneration in mice.
Hagiwara Y, Sasaoka T, Araishi K, Imamura M, Yorifuji H, Nonaka I, Ozawa E, Kikuchi T
Hum. Mol. Genet., 9(20):3047-3054 (2000). 11115849

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cav3
MGI:107570		caveolin 36Cav3<tm1Ncnp >
MGI:2684578		targeted mutation 1, Tateki Kikuchi
  • creatine phosphokinase, elevated serum(MedGEN)

  • distal myopathy, Tateyama type(MedGEN)

  • hypertrophic cardiomyopathy 1(MedGEN)
    • more 3 Diseases
  • long QT syndrome 9(MedGEN)

  • rippling muscle disease 2(MedGEN)

  • rippling muscle disease(DisGeNET)
    • neo neomycin resistance gene (E. coli)6

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal adipocyte glucose uptake (MP:0004185)

  • abnormal atrium myocardial trabeculae morphology (MP:0010581)

  • abnormal circulating lipid level (MP:0003949)

  • abnormal glucose homeostasis (MP:0002078)

  • abnormal heart atrium morphology (MP:0003105)
    • more 11 phenotypes
  • abnormal hepatic glucose production (MP:0020101)

  • abnormal muscle cell glucose uptake (MP:0004130)

  • abnormal muscle development (MP:0000733)

  • abnormal muscle fiber morphology (MP:0004087)

  • abnormal myocardial fiber morphology (MP:0000278)

  • centrally nucleated skeletal muscle fibers (MP:0009404)

  • impaired glucose tolerance (MP:0005293)

  • increased circulating insulin level (MP:0002079)

  • insulin resistance (MP:0005331)

  • muscle degeneration (MP:0000749)

  • thick ventricular wall (MP:0002953)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE coli neo, mouse caveolin-3(Cav3) genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 9, 3047-3054 (2000).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data