Strain Data Sheet

RBRC02389

Strain Information

Image
BRC No.RBRC02389
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129P2(B6)-Cd180<tm1Kmiy>
Former Common nameBalb/c-RP105 KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainBALB/cCrSlc
Appearance
Strain development
Strain description
Colony maintenance
References
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbrauker I, Rajewsky K, Kimoto M, Tarakhovsky A
J. Exp. Med., 192, 23-29 (2000). 10880523

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cd180
MGI:1194924		CD180 antigen13Cd180<tm1Kmiy>
MGI:3581654		targeted mutation 1, Kensuke Miyake
neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal humoral immune response(MP:0001800)

  • decreased IgG2a level(MP:0008496)

  • decreased IgG2b level(MP:0008497)

  • decreased IgG3 level(MP:0008498)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Cd180 genome DNA, E. coli neo, mouse PGK-1 promoter
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 192, 23-29 (2000).
    DepositorKensuke Miyake (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data