Strain Data Sheet

RBRC02390

Strain Information

Image
BRC No.RBRC02390
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Cd180<tm1Kmiy>
Former Common nameC57BL/6-RP105 KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6NCrSlc
Appearance
Strain development
Strain description
Colony maintenance
References
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbrauker I, Rajewsky K, Kimoto M, Tarakhovsky A
J. Exp. Med., 192, 23-29 (2000). 10880523

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cd180
MGI:1194924		CD180 antigen13Cd180<tm1Kmiy>
MGI:3581654		targeted mutation 1, Kensuke Miyake
neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal humoral immune response(MP:0001800)

  • decreased IgG2a level(MP:0008496)

  • decreased IgG2b level(MP:0008497)

  • decreased IgG3 level(MP:0008498)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Cd180 genome DNA, E. coli neo
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 192, 23-29 (2000).
    DepositorKensuke Miyake (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-
    Mouse of the Month Oct 2015

    BRC mice in Publications

    No Data