Strain Data Sheet

RBRC02392

Strain Information

Image
BRC No.RBRC02392
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Jdp2<tm2Kkyo>/Rbrc
Former Common nameB6.129P2-Jundm2<tm2>
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Yokoyama KK and Pan J, RIKEN BioResource Center. The E14 ES cells originated from 129P2/OlaHsd were used. The knock-out mice are under backcrossing to C57BL/6J strain.
Strain descriptionJDP2 coding region was disrupted.
Colony maintenanceHeterozygote x Wild-type [C57BL/6J]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site12Frt
Frt yeast FRT (flippase recombination target) site12Frt
Jdp2
MGI:1932093		Jun dimerization protein 212Jdp2<tm2Kkyo>
MGI:4849487		targeted mutation 2, Kazunari K Yokoyama
loxP phage P1 loxP12loxP
loxP phage P1 loxP12loxP
neo neomycin resistance gene (E. coli)12 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cell cycle(MP:0003077)

  • abnormal cell differentiation(MP:0005076)

  • abnormal fat cell morphology(MP:0009115)

  • abnormal skin physiology(MP:0005501)

  • enhanced wound healing(MP:0002724)
    • more 3 phenotypes
  • increased cell proliferation(MP:0000351)

  • short tail(MP:0000592)

  • thick skin(MP:0001200)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, S. cerevisiae Frt sites, mouse JDP2 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER Dr. Kazushige YOKOYAMA (kazu@kmu.edu.tw).
    DepositorYuichi Obata (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Yao C, Yao GQ, Sun BH, Zhang C, Tommasini SM, Insogna K.
    The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.
    J Biol Chem 289(10) 6775-6790(2014) 24394418