Strain Data Sheet

RBRC02408

Strain Information

Image
BRC No.RBRC02408
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(cry-GDF1,lacz)6Hmd
Former Common namecry-GDF1-IRES-lacZ (6)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Long-range action of Nodal requires interaction with GDF1.
Tanaka C, Sakuma R, Nakamura T, Hamada H, Saijoh Y
Genes Dev., 21, 3272-3282 (2007). 18079174

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gdf1
MGI:95683		growth differentiation factor 1UNGdf1 11-kb upstream region of Cryptic and hsp68 promoter
  • congenital heart defects, multiple types, 6(MedGEN)

  • progressive myoclonic epilepsy type 8(MedGEN)

  • right atrial isomerism(MedGEN)
    • IRES internal ribosomal entry site (EMCV)UN
    lacZ beta-galactosidase (E. coli)UN

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal left-right axis symmetry of the somites(MP:0005224)
    • Detailed phenotype data

    Ordering Information

    Donor DNAマウス由来crypticエンハンサー, GDF1 cDNA, hspプロモーター, ウイルス由来タンパク合成開始シグナル(IRES), 大腸菌由来lacZ遺伝子
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 21, 3272-3282 (2007).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data