Strain Information | |
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Image | |
BRC No. | RBRC02419 |
Type | Targeted Mutation Congenic![]() |
Species | Mus musculus |
Strain name | B6.Cg-Drd1a<tm1Mok> Drd2<tm1Mok> |
Former Common name | D1RD2R KO, B6-D1R/D2R KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences. |
Strain description | D1R (Drd1a) and D2R (Drd2) genes double knockout mice. |
Colony maintenance | |
References | Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M Genes Cells. 1(2):253-68 (1996). 9140068Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty. Tran A H, Uwano T, Kimura T, Hori E, Katsuki M, Nishijo H, Ono T J. Neurosci., 28(50):13390-13400 (2008). 19074012 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Drd1 MGI:99578 | dopamine receptor D1 | 13 | Drd1<tm1Mok> MGI:3829942 | targeted mutation 1, Motoya Katsuki | mouse phosphoglycerate kinase promoter (PGK promoter) | ||
Ecogpt | E.coli xanthine phosphoribosyltransferase | 13 | Ecogpt | mouse phosphoglycerate kinase promoter (PGK promoter) | |||
neo | neomycin resistance gene (E. coli) | 13 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
Drd2 MGI:94924 | dopamine receptor D2 | 9 | Drd2<tm1Mok> MGI:3576789 | targeted mutation 1, Motoya Katsuki | |||
neo | neomycin resistance gene (E. coli) | 9 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Phenotype annotation from literatures by Mammalian phenotype ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase(Ecogpt), herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse Drd1a genomic DNA, mouse Drd2 genomic DNA |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 13390-13400 (2008). Genes Cells, 1, 253-268 (1996).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |