Strain Data Sheet

RBRC02419

Strain Information

Image
BRC No.RBRC02419
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Drd1a<tm1Mok> Drd2<tm1Mok>
Former Common nameD1RD2R KO, B6-D1R/D2R KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD1R (Drd1a) and D2R (Drd2) genes double knockout mice.
Colony maintenance
References
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M
Genes Cells. 1(2):253-68 (1996). 9140068

Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty.
Tran A H, Uwano T, Kimura T, Hori E, Katsuki M, Nishijo H, Ono T
J. Neurosci., 28(50):13390-13400 (2008). 19074012

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd1
MGI:99578
dopamine receptor D113Drd1<tm1Mok>
MGI:3829942
targeted mutation 1, Motoya Katsukimouse phosphoglycerate kinase promoter (PGK promoter)
Ecogpt E.coli xanthine phosphoribosyltransferase13Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
neo neomycin resistance gene (E. coli)13 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
Drd2
MGI:94924
dopamine receptor D29Drd2<tm1Mok>
MGI:3576789
targeted mutation 1, Motoya Katsuki
  • cocaine dependence(DisGeNET)
  • neo neomycin resistance gene (E. coli)9 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal circulating hormone level (MP:0005418)

  • abnormal single cell response (MP:0003463)

  • abnormal synaptic plasticity (MP:0004859)

  • darkened coat color (MP:0005409)

  • enlarged pituitary intermediate lobe (MP:0008370)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase(Ecogpt), herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse Drd1a genomic DNA, mouse Drd2 genomic DNA
    Research applicationNeurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 13390-13400 (2008). Genes Cells, 1, 253-268 (1996).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data