Strain Data Sheet

RBRC02431

Strain Information

Image
BRC No.RBRC02431
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>
Former Common nameD2R D3R D4R multiple KO, B6-D2R/D3R/D4R KO
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD2R (Drd2), D3R (Drd3) and D4R (Drd4) triple knockout mice.
Colony maintenance
References
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M
Genes Cells. 1(2):253-68 (1996). 9140068

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd3
MGI:94925		dopamine receptor D316Drd3<tm1Mok>
MGI:6376625		targeted mutation 1, Motoya Katsuki
  • schizophrenia(MedGEN)

  • tremor, hereditary essential, 1(MedGEN)
    • Ecogpt E.coli xanthine phosphoribosyltransferase16Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
    neo neomycin resistance gene (E. coli)16 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Drd4
    MGI:94926    		dopamine receptor D47Drd4<tm1Mok>
    MGI:6376626    		targeted mutation 1, Motoya Katsuki
  • attention deficit-hyperactivity disorder(MedGEN)
    • Ecogpt E.coli xanthine phosphoribosyltransferase7Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
    neo neomycin resistance gene (E. coli)7 mouse RNA polymerase II large subunit promoter
    Drd2
    MGI:94924    		dopamine receptor D29Drd2<tm1Mok>
    MGI:3576789    		targeted mutation 1, Motoya Katsuki
    neo neomycin resistance gene (E. coli)9 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating hormone level(MP:0005418)

  • abnormal single cell response(MP:0003463)

  • darkened coat color(MP:0005409)

  • enlarged pituitary intermediate lobe(MP:0008370)

  • increased pituitary hormone level(MP:0003973)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase (Ecogpt), mouse Dopamine receptor 2 genomic DNA, mouse Dopamine receptor 3 genomic DNA, mouse Dopamine receptor 4 genomic DNA
    Research applicationNeurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 1, 253-268 (1996).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data