Strain Data Sheet

RBRC02432

Strain Information

Image
BRC No.RBRC02432
TypeTransgeneCartagena
SpeciesMus musculus
Strain name(hRN8-12 x hAG2-5)F1
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background.
Strain descriptionTsukuba Hypertensive Mice.
Colony maintenance
References
Tissue-specific expression of the human renin gene in transgenic mice.
Fukamizu A, Seo M S, Hatae T, Yokoyama M, Nomura T, Katsuki M, Murakami K
Biochem. Biophys. Res. Commun., 165, 826-832 (1989). 2480785

Expression of the human angiotensinogen gene in transgenic mice and transfected cells.
Takahashi S, Fukamizu A, Hasegawa T, Yokoyama M, Nomura T, Katsuki M, Murakami K
Biochem. Biophys. Res. Commun., 180, 1103-1109 (1991). 1659395

Health Report

Examination Date / Room / Rack2024/09/09Room:3-2Rack:CSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
AGT Angiotensinogen (human)UNAGT
REN1 renin 1 structural (human)UNREN1

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal chorion morphology(MP:0002836)

  • abnormal maternal decidual layer morphology(MP:0004256)

  • abnormal placenta morphology(MP:0001711)

  • abnormal pregnancy(MP:0009661)

  • abnormal renal glomerulus morphology(MP:0005325)
    • more 16 phenotypes
  • abnormal spongiotrophoblast cell morphology(MP:0008959)

  • cardiac fibrosis(MP:0003141)

  • convulsive seizures(MP:0000947)

  • decreased cardiac muscle contractility(MP:0005140)

  • decreased fetal weight(MP:0009431)

  • decreased frequency of paradoxical sleep(MP:0012286)

  • delayed parturition(MP:0012008)

  • heart inflammation(MP:0001853)

  • hemorrhage(MP:0001914)

  • hypertension(MP:0000231)

  • increased heart weight(MP:0002833)

  • increased systemic arterial systolic blood pressure(MP:0006144)

  • increased urine protein level(MP:0002962)

  • maternal effect(MP:0003718)

  • myocardium hypertrophy(MP:0010633)

  • pregnancy-related premature death(MP:0008028)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman angiotensinogen genomic DNA ,human renin1 genomic DNA (10 exons, 9 introns and native promoter)
    Research applicationCell Biology Research
    Hematological Research
    Mouse Models for Human Disease
    covid19_progression
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochem. Biophys. Res. Commun., 165, 826-832 (1989).
    Biochem. Biophys. Res. Commun., 180, 1103-1109 (1991).
    DepositorAkiyoshi Fukamizu (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-
    Mouse of the Month May 2012
    Systolic blood pressure

    BRC mice in Publications

    Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A.
    Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure.
    PLoS One 12(8) e0181055(2017) 28800627
    Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A, Arakawa K.
    Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice.
    Biomed Rep 1(3) 359-364(2013) 24648949
    Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T.
    Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation.
    J Am Soc Nephrol 23(6) 997-1007(2012) 22440899