Strain Data Sheet

RBRC02440

Strain Information

Image
BRC No.RBRC02440
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Drd1a<tm1Mok> Drd5<tm1Mok>
Former Common nameB6-D1R/D5R KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD1R (Drd1a) and D5R (Drd5) genes double knockout mice.
Colony maintenance
References
Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty.
Tran A H, Uwano T, Kimura T, Hori E, Katsuki M, Nishijo H, Ono T
J. Neurosci., 28(50):13390-13400 (2008). 19074012

Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H, Kodama T, Takada M
PLoS One, 8(10):e75975 (2013). 24155877

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd1
MGI:99578		dopamine receptor D113Drd1<tm1Mok>
MGI:3829942		targeted mutation 1, Motoya Katsuki
Ecogpt E.coli xanthine phosphoribosyltransferase13Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
neo neomycin resistance gene (E. coli)13 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal synaptic plasticity(MP:0004859)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse Dopamine receptor1, 5 genomic DNA, E. coli xanthine phosphoribosyltransferase (Ecogpt)
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 13390-13400 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data