Strain Data Sheet

RBRC02467

Strain Information

Image
BRC No.RBRC02467
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Hprt1<tm1Mok>
Former Common nameHPRT-KO, B6-Hprt KO
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionHprt gene knockout mice.
Colony maintenanceHeterozygote (female), Hemizygote (male) x Wild-type [C57BL/6JJcl]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hprt1
MGI:96217		hypoxanthine phosphoribosyltransferase 1XHprt1<tm1Mok>
MGI:6377673		targeted mutation 1, Motoya Katsuki
  • hypoxanthine guanine phosphoribosyltransferase partial deficiency(DisGeNET, MedGEN)

  • Lesch-Nyhan syndrome(DisGeNET, MedGEN)
    • neo neomycin resistance gene (E. coli)X herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Hprt genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Aizawa S, Nishimura K, Mondejar GS, Kumar A, Bui PL, Tran YTH, Kuno A, Muratani M, Kobayashi S, Nabekura T, Shibuya A, Sugihara E, Sato TA, Fukuda A, Hayashi Y, Hisatake K.
    Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming.
    Stem Cell Reports 17(1) 53-67(2022) 34919813