Strain Information | |
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Image | |
BRC No. | RBRC02479 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6;129S-Hras1<tm1Mok> Grin2a<tm1Nak> Drd1a<tm1Mok> Drd5<tm1Mok> |
Former Common name | B6-Hras/NR2A/D1R/D5R KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | |
Appearance | |
Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences. |
Strain description | Hras, NR2A (Grin2a), D1R (Drd1a) and D5R (Drd5) genes multiple knockout mice. |
Colony maintenance | |
References | Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M, Nakanishi S J. Neurosci., 16, 7859-7867 (1996). 8987814Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T, Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M Oncogene, 19, 2951-2956 (2000). 10871846Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty. Tran A H, Uwano T, Kimura T, Hori E, Katsuki M, Nishijo H, Ono T J. Neurosci., 28(50):13390-13400 (2008). 19074012Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice. Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H, Kodama T, Takada M PLoS One, 8(10):e75975 (2013). 24155877 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Drd1 MGI:99578 | dopamine receptor D1 | 13 | Drd1<tm1Mok> MGI:3829942 | targeted mutation 1, Motoya Katsuki | |||
Ecogpt | E.coli xanthine phosphoribosyltransferase | 13 | Ecogpt | mouse phosphoglycerate kinase promoter (PGK promoter) | |||
neo | neomycin resistance gene (E. coli) | 13 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
Grin2a MGI:95820 | glutamate receptor, ionotropic, NMDA2A (epsilon 1) | 16 | Grin2a<tm1Nak> MGI:1928506 | targeted mutation 1, Shigetada Nakanishi | |||
neo | neomycin resistance gene (E. coli) | 16 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
Drd5 MGI:94927 | dopamine receptor D5 | 5 | Drd5<tm1Mok> MGI:5569103 | targeted mutation 1, Motoya Katsuki | |||
Ecogpt | E.coli xanthine phosphoribosyltransferase | 5 | Ecogpt | mouse phosphoglycerate kinase promoter (PGK promoter) | |||
neo | neomycin resistance gene (E. coli) | 5 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
Hras MGI:96224 | Harvey rat sarcoma virus oncogene | 7 | Hras<tm1Mok> MGI:2386128 | targeted mutation 1, Motoya Katsuki | |||
neo | neomycin resistance gene (E. coli) | 7 |
Phenotype | |
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Phenotype annotation from literatures by Mammalian phenotype ontology | more 11 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse NMDAR2A genomic DNA, mouse Hras genomic DNA, mouse Drd1a genomic DNA, mouse Drd5 genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase(Ecogpt) |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 19, 2951-2956 (2000). J. Neurosci., 16, 7859-7867 (1996). J. Neurosci., 28, 13390-13400 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |