Strain Information | |
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Image | |
BRC No. | RBRC02591 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.Cg-Git2<tm1Hsb>/SiaRbrc |
Former Common name | GIT2(-) (Acc. No. CDB0414K) |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Mazaki Y, Hashimoto S, Tsujimura T, Morishige M, Hashimoto A, Aritake K, Yamada A, Nam J M, Kiyonari H, Nakao K, Sabe H Nat. Immunol., 7, 724-731 (2006). 16715100 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Git2 MGI:1347053 | GIT ArfGAP 2 | 5 | Git2<tm1Hsb> MGI:3664625 | targeted mutation 1, Hisataka Sabe | |||
neo | neomycin resistance gene (E. coli) | 5 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 3 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | E. coli Neo, Phage P1 loxP、 mouse PKG promoter, mouse PKG 3’ end |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | (1) The RECIPIENT shall obtain a prior agreement from Dr. Hisataka SABE (sabe@obi.or.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0414K and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Nat Immunol. 2006 Jul; 7 (7): 724-31. (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. |
Depositor | RIKEN CDB (RIKEN CDB) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Le H, Wang Y, Zhou J, Li D, Gong Z, Zhu F, Wang J, Tian C, Cai W, Wu J. Git2 deficiency promotes MDSCs recruitment in intestine via NF-κB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis. Mucosal Immunol (2024) 39074614 |
Hao YE, He DF, Yin RH, Chen H, Wang J, Wang SX, Zhan YQ, Ge CH, Li CY, Yu M, Yang XM. GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice. FEBS Open Bio 5 688-704(2015) 26380813 |
Wei J, Wei C, Wang M, Qiu X, Li Y, Yuan Y, Jin C, Leng L, Wang J, Yang X, He F. The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling. Proc Natl Acad Sci U S A 111(24) 8883-8(2014) 24879442 |