Strain Data Sheet

RBRC02660

Strain Information

Image
BRC No.RBRC02660
TypeCongenic
SpeciesMus musculus
Strain nameA.AKITA-(D6Mit286-D6Mit148)
Former Common nameAkita-Dbm1 sub-congenic, A/J
H-2 Haplotype
ES Cell line
Background strainA
Appearance
Strain developmentDeveloped by Mistuo Itakura, The University of Tokushima and Dr. Takeshita, Astellas Pharm Inc. in 2005.
Strain descriptionThis stain carries glucose metabolism-related loci from Chr 10 (D6Mit286-D6Mit148) of AKITA backcrossed to A/J.
Colony maintenance
References
Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.
Takeshita S, Moritani M, Kunika K, Inoue H, Itakura M
Mamm. Genome, 17, 927-940 (2006). 16964447

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dbm1
MGI:3664266		diabetes modifier 16Dbm1 AKITA

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • increased body weight(MP:0001260)

  • increased circulating glucose level(MP:0005559)

  • increased circulating insulin level(MP:0002079)

  • increased circulating insulin-like growth factor I level(MP:0004702)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Takeshita et al., Mammalian Genome, 17, 927-940 (2006). Takeshita et al., Mammalian Genome, under submissionThe RECIPIENT of BIOLOGICAL resource shall obtain a prior written consent on use of it from the DEPOSITOR Dr. Mitsuo Itakura, Institute for Genome Research, The University of Tokushima. The RECIPIENT must send a copy of the APPROVAL FORM approved by Dr. Mitsuo Itakura to Phamacology Research Labs, Astellas Pharma Inc. (Mr. Shigeru Takeshita) by fax (+81-29-847-1536) immediately, and then send it by mail. The RECIPIENT shall obtain a license from the DEPOSITOR in the case of application for any patents or commercial use with the reslts from the use of the BIOLOGICAL RESOURCE.
    DepositorAstellas Pharma Inc. and Tokushima University (Astellas Pharma Inc., Tokushima University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data