Strain Data Sheet

RBRC02671

Strain Information

Image
BRC No.RBRC02671
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S2-Adam1b<tm1Tba>
Former Common nameAdamlb KO, C57BL/6
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization.
Kim E, Yamashita M, Nakanishi T, Park K E, Kimura M, Kashiwabara S, Baba T
J. Biol. Chem., 281, 5634-5639 (2006) 16407235

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Adam1b
MGI:2429506		a disintegrin and metallopeptidase domain 1b5Adam1b<tm1Tba>
MGI:3628759		targeted mutation 1, Tadashi Baba
neo neomycin resistance gene (E. coli)5 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal sperm head morphology(MP:0009230)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHerpes simplex virus thymidine kinase promoter, Herpes simplex virus thymidine kinase polyadenylation sequence, Escherichia coli neomycin resistance gene, Mouse Adam1b genomic DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTadashi Baba (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data