Strain Data Sheet

RBRC02675

Strain Information

Image
BRC No.RBRC02675
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S2-Prss21<tm1Tba>
Former Common nameTesp5/Prss21 KO, C57BL/6
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
A mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein.
Honda A, Yamagata K, Sugiura S, Watanabe K, Baba T
J. Biol. Chem., 277, 16976-16984 (2002) 11861648

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Prss21
MGI:1916698		serine protease 2117Prss21
neo neomycin resistance gene (E. coli)17 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • impaired acrosome reaction(MP:0004542)

  • impaired fertilization(MP:0000242)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHerpes simplex virus thymidine kinase promoter, Herpes simplex virus thymidine kinase polyadenylation sequence,Escherichia coli neomycin-resistance gene, Mouse Prss21/Tesp5 genomic DNA
    Research applicationReproductive Biology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTadashi Baba (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data