Strain Data Sheet

RBRC02677

Strain Information

Image
BRC No.RBRC02677
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR;129X1-Acr<tm1Tba>
Former Common nameAcrosin KO, ICR
H-2 Haplotype
ES Cell lineA3-1 [129X1/SvJ]
Background strain
Appearance
Strain developmentDeveloped by Tadashi Baba, University of Tsukuba in 1994.
Strain description
Colony maintenance
References
Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.
Baba T, Azuma S, Kashiwabara S, Toyoda Y
J. Biol. Chem., 269, 31845-31849 (1994) 7989357

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Acr
MGI:87884		acrosin prepropeptide15Acr<tm1Tba>
MGI:2180087		targeted mutation 1, Tadashi Baba
neo neomycin resistance gene (E. coli)15 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • delayed fertilization(MP:0005411)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHerpes simplex virus thymidine kinase promoter, Escherichia coli neomycin resistance gene, Herpes simplex virus thymidine kinase polyadenylation sequence, Mouse acrosin genomic DNA
    Research applicationReproductive Biology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTadashi Baba (University of Tsukuba)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data