Strain Data Sheet

RBRC02678

Strain Information

Image
BRC No.RBRC02678
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR;129S2-Adam1a<tm1Tba>
Former Common nameICR;129S2-Adam1a<tm1Tba>
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain developmentDeveloped by Tadashi Baba, Universty of Tsukuba in 2002.
Strain description
Colony maintenance
References
Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface.
Nishimura H, Kim E, Nakanishi T, Baba T
J. Biol. Chem., 279, 34957-34962 (2004) 15194697

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Adam1a
MGI:2429504		a disintegrin and metallopeptidase domain 1a5Adam1a<tm1Tba>
MGI:3052660		targeted mutation 1, Tadashi Baba
neo neomycin resistance gene (E. coli)5 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal fertilization(MP:0005410)

  • asthenozoospermia(MP:0002675)

  • male infertility(MP:0001925)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHerpes simplex virus thymidine kinase promoter, Herpes simplex virus thymidine kinase polyadenylation sequence, Escherichia coli neomycin-resistance gene, Mouse Adam1a genomic DNA
    Research applicationReproductive Biology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTadashi Baba (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data