Strain Data Sheet

RBRC02685

Strain Information

Image
BRC No.RBRC02685
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6CBA-Tnxb<tm1Kmat>
Former Common nameTnx-/-(A1), TNX-/- A1
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearanceagouti [A/A B/B C/C]
Strain developmentDeveloped by Dr. Kenichi Matsumoto, Hokkaido University in 2001. C57BL/6 and CBA mixed background.
Strain descriptionTnxb, tenascin XB knock-out mice. This strain is useful to study the biological function of extracellular matrix tenascin-X in vivo. TNX-/- A line.
Colony maintenanceHomozygote x Homozygote
References
Tumour invasion and metastasis are promoted in mice deficient in tenascin-X.
Matsumoto K, Takayama N, Ohnishi J, Ohnishi E, Shirayoshi Y, Nakatsuji N, Ariga H
Genes Cells, 6, 1101-1111 (2001). 11737270

Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Matsumoto K, Minamitani T, Orba Y, Sato M, Sawa H, Ariga H
Exp. Cell Res., 297, 404 (2004). 15212943

Triglyceride accumulation and altered composition of triglyceride-associated fatty acids in the skin of tenascin-X-deficient mice.
Matsumoto K, Sato T, Oka S, Orba Y, Sawa H, Kabayama K, Inokuchi J, Ariga H
Genes Cells, 9, 737 (2004). 15298681

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnxb
MGI:1932137		tenascin XB17Tnxb<tm1Kmat >
MGI:3053791		targeted mutation 1, Ken-ichi Matsumoto
neo neomycin resistance gene (E. coli)17 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cutaneous collagen fibril morphology(MP:0008438)

  • abnormal tumor susceptibility(MP:0002166)

  • increased susceptibility to induced morbidity/mortality(MP:0009763)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE.coli neo, mouse tenascin-X genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter)
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 6, 1101-1111 (2001). The RECIPIENT must contact the DEPOSITOR in the case of application for any publications, patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKen-ichi Matsumoto (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data