Strain Data Sheet

RBRC02687

Strain Information

Image
BRC No.RBRC02687
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tnc<tm1Sia> Tnxb<tm1Kmat>
Former Common nameTnx-/-(A1),Tnc-/- double deficient, TNX-/-(A1),TNC-/-
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Mice develop normally without tenascin.
Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S
Genes Dev., 6, 1821-1831 (1992). 1383086

Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse.
Koyama Y, Kusubata M, Yoshiki A, Hiraiwa N, Ohashi T, Irie S, Kusakabe M
J. Invest. Dermatol. 111, 930 (1998). 9856798

Tumour invasion and metastasis are promoted in mice deficient in tenascin-X.
Matsumoto K, Takayama N, Ohnishi J, Ohnishi E, Shirayoshi Y, Nakatsuji N, Ariga H
Genes Cells, 6, 1101-1111 (2001). 11737270

Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Matsumoto K, Minamitani T, Orba Y, Sato M, Sawa H, Ariga H
Exp. Cell Res., 297, 404 (2004) 15212943

Triglyceride accumulation and altered composition of triglyceride-associated fatty acids in the skin of tenascin-X-deficient mice.
Matsumoto K, Sato T, Oka S, Orba Y, Sawa H, Kabayama K, Inokuchi J, Ariga H
Genes Cells, 9, 737 (2004) 15298681

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnxb
MGI:1932137		tenascin XB17Tnxb<tm1Kmat >
MGI:3053791		targeted mutation 1, Ken-ichi Matsumoto
neo neomycin resistance gene (E. coli)17 mouse phosphoglycerate kinase promoter (PGK promoter)
Tnc
MGI:101922		tenascin C4Tnc<tm1Sia >
MGI:2148540		targeted mutation 1, Shinichi Aizawa
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)
    • lacZ beta-galactosidase (E. coli)4
    neo neomycin resistance gene (E. coli)4 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal circadian behavior(MP:0020467)

  • abnormal cutaneous collagen fibril morphology(MP:0008438)

  • abnormal serotonin level(MP:0005322)

  • abnormal tumor susceptibility(MP:0002166)
    • more 5 phenotypes
  • decreased dopamine level(MP:0005643)

  • hyperactivity(MP:0001399)

  • impaired swimming(MP:0001522)

  • increased stereotypic behavior(MP:0001409)

  • increased susceptibility to induced morbidity/mortality(MP:0009763)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA, mouse tenascin-X genomic DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Jpn J. Cancer Res., 73, 968-975 (2002).The RECIPIENT must contact the DEPOSITOR in the case of application for any publications, patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKen-ichi Matsumoto (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data