Strain Data Sheet

RBRC02690

Strain Information

Image
BRC No.RBRC02690
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6CBA-Rbms1<tm1Hiro>
Former Common nameMssp-/-, MSSP-/-
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Hiroyoshi Ariga, Hokkaido University Faculty of Pharmaceutical Sciences in 2001.
Strain description
Colony maintenance
References
Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice.
Fujimoto M, Matsumoto K, Iguchi-Ariga S M, Ariga H
Genes Cells, 6, 1067-1075 (2001). 11737267

Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice.
Nomura J, Matsumoto K, Iguchi-Ariga S M, Ariga H
Exp. Cell Res., 305, 324 (2005). 15817157

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Rbms1
MGI:1861774		RNA binding motif, single stranded interacting protein 12Rbms1<tm1Hiro>
MGI:2384095		targeted mutation 1, Hiroyoshi Ariga
neo neomycin resistance gene (E. coli)2 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased circulating progesterone level(MP:0005185)

  • decreased embryo size(MP:0001698)

  • embryonic growth retardation(MP:0003984)

  • embryonic lethality during organogenesis, incomplete penetrance(MP:0011108)

  • prenatal lethality, incomplete penetrance(MP:0011101)
    • more 1 phenotypes
  • small uterus(MP:0002637)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E.coli neo, mouse Rbms1 genomic DNA
    Research applicationCancer Research
    Immunology and Inflammation Research
    Reproductive Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 6, 1067-1075 (2001).
    DepositorHiroyoshi Ariga (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data