Strain Data Sheet

RBRC02702

Strain Information

Image
BRC No.RBRC02702
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CAG-Slc11a2)N
Former Common nameDMT1 Tg N
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Appearance
Strain development
Strain description
Colony maintenance
References
Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload.
Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S
Am. J. Pathol., 177, 677-685 (2010). 20558581

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Slc11a2 solute carrier familly 11 (proton-coupled divalent metal ion transporters), member 2 (rat)UNSlc11a2 CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal intestinal absorption(MP:0001666)

  • abnormal intestinal iron level(MP:0008740)

  • abnormal intestinal mucosa morphology(MP:0000511)

  • abnormal small intestinal villus morphology(MP:0008108)

  • anemia(MP:0001577)
    • more 6 phenotypes
  • decreased body weight(MP:0001262)

  • gastrointestinal hemorrhage(MP:0000465)

  • increased cellular sensitivity to oxidative stress(MP:0008412)

  • increased intestinal iron level(MP:0020369)

  • intestinal ulcer(MP:0000512)

  • small intestinal villus atrophy(MP:0014078)
    • Detailed phenotype data

    Ordering Information

    Donor DNArat DMT1 (Nramp2) cDNA, CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPENT is requested to submit the abstract of the research project to the DEPOSITOR. The RECIPIENT agree to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorShinya Toyokuni (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. CAGGS MTA (English)
    5. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data