Strain Data Sheet

RBRC02711

Strain Information

Image
BRC No.RBRC02711
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Osmr<tm1Mtan>
Former Common nameOncostatin M receptor knockout mouse, OSMR-KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Minoru Tanaka in 1999.
Strain descriptionOsmr knock-out mice. Osmr, Oncostain M receptor is an alternative subunit that activated by Osm. Osm is a multifunctional cytokine that belongs to the interleukin 6 family, considered to play a role in hematopoiesis. Homozygous mutant mice are viable and fertile, but show a mild anemia and recovery delay of erythrocytes from chemically induced acute hemolysis.
Colony maintenanceHeterozygote x Wild-type [C57BL/6CrSlc]
References
Targeted disruption of oncostatin M receptor results in altered hematopoiesis.
Tanaka M, Hirabayashi Y, Sekiguchi T, Inoue T, Katsuki M, Miyajima A
Blood, 102, 3154-3162 (2003). 12855584

Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice.
Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A
Hepatology, 39, 635-644 (2004). 14999682

Health Report

Examination Date / Room / Rack2025/01/20Room:3-CRack:HSentinel mouse program
2024/10/21Room:3-CRack:HSentinel mouse program
2024/07/22Room:3-CRack:HSentinel mouse program
2024/04/22Room:3-CRack:HSentinel mouse program
2024/01/22Room:3-CRack:HSentinel mouse program
2023/10/23Room:3-CRack:HSentinel mouse program
2023/07/24Room:3-CRack:HSentinel mouse program
2023/04/24Room:3-CRack:HSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Osmr
MGI:1330819		oncostatin M receptor15Osmr<tm1Mtan>
MGI:2680723		targeted mutation 1, Minoru Tanaka
  • amyloidosis, primary localized cutaneous, 1(MedGEN)
    • lacZ beta-galactosidase (E. coli)15
    neo neomycin resistance gene (E. coli)15 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal adipose tissue morphology(MP:0000003)

  • abnormal adipose tissue physiology(MP:0005666)

  • abnormal circulating chemokine level(MP:0010209)

  • abnormal circulating serum amyloid protein level(MP:0010214)

  • abnormal common myeloid progenitor cell morphology(MP:0006410)
    • more 40 phenotypes
  • abnormal definitive hematopoiesis(MP:0002123)

  • abnormal erythroid progenitor cell morphology(MP:0008801)

  • abnormal liver physiology(MP:0000609)

  • abnormal megakaryocyte progenitor cell morphology(MP:0002413)

  • abnormal muscle physiology(MP:0002106)

  • adipose tissue inflammation(MP:0020386)

  • anemia(MP:0001577)

  • decreased circulating adiponectin level(MP:0030968)

  • decreased circulating interleukin-10 level(MP:0008594)

  • decreased erythrocyte cell number(MP:0002875)

  • decreased hematocrit(MP:0000208)

  • decreased liver glycogen level(MP:0010398)

  • decreased megakaryocyte cell number(MP:0008255)

  • hematopoietic system phenotype(MP:0005397)

  • hepatic steatosis(MP:0002628)

  • impaired glucose tolerance(MP:0005293)

  • impaired liver regeneration(MP:0005517)

  • increased body weight(MP:0001260)

  • increased circulating cholesterol level(MP:0005178)

  • increased circulating free fatty acids level(MP:0001554)

  • increased circulating glucose level(MP:0005559)

  • increased circulating insulin level(MP:0002079)

  • increased circulating interleukin-10 level(MP:0008593)

  • increased circulating interleukin-6 level(MP:0008596)

  • increased circulating leptin level(MP:0005669)

  • increased circulating triglyceride level(MP:0001552)

  • increased circulating tumor necrosis factor level(MP:0008553)

  • increased epididymal fat pad weight(MP:0009288)

  • increased food intake(MP:0011939)

  • increased inflammatory response(MP:0001846)

  • increased liver cholesterol level(MP:0010027)

  • increased liver triglyceride level(MP:0009355)

  • increased liver weight(MP:0002981)

  • increased pancreatic beta cell number(MP:0003645)

  • increased subcutaneous adipose tissue amount(MP:0010934)

  • increased susceptibility to diet-induced obesity(MP:0005658)

  • increased white fat cell size(MP:0009118)

  • insulin resistance(MP:0005331)

  • polyphagia(MP:0001433)

  • thrombocytopenia(MP:0003179)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, E. coli lacZ, mouse Osmrg genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Hematological Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004). The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Chiome Bioscience Inc. Email:knakamura@chiome.co.jp).
    DepositorAtsushi Miyajima (The University of Tokyo)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Feng Y, Yuan Y, Xia H, Wang Z, Che Y, Hu Z, Deng J, Li F, Wu Q, Bian Z, Zhou H, Shen D, Tang Q.
    OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
    J Transl Med 21(1) 290(2023) 37120549
    Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B.
    Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
    Acta Neuropathol 144(2) 259-281(2022) 35666306
    Zhang X, Li J, Qin JJ, Cheng WL, Zhu X, Gong FH, She Z, Huang Z, Xia H, Li H.
    Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages.
    J Lipid Res 58(5) 895-906(2017) 28258089
    Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
    The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
    Nat Commun 8 13946(2017) 28067314
    Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.
    Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
    Glia 63(10) 1729-37(2015) 25921393
    Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H.
    Oncostatin M Confers Neuroprotection against Ischemic Stroke.
    J Neurosci 35(34) 12047-62(2015) 26311783