Strain Data Sheet

RBRC02740

Strain Information

Image
BRC No.RBRC02740
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Klk8<tm1Shio>
Former Common nameNeuropsin-/-, NP-/-, Neuropsin knock-out mouse, NPKO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice.
Hirata A, Yoshida S, Inoue N, Matsumoto-Miyai K, Ninomiya A, Taniguchi M, Matsuyama T, Kato K, Iizasa H, Kataoka Y, Yoshida N, Shiosaka S
Mol. Cell Neurosci., 17, 600-610 (2001). 11273653

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Klk8
MGI:1343327		kallikrein related-peptidase 87Klk8<tm1Shio>
MGI:2678312		targeted mutation 1, Sadao Shiosaka
neo neomycin resistance gene (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal GABAergic neuron morphology(MP:0003245)

  • abnormal brain interneuron morphology(MP:0004101)

  • abnormal dentate gyrus subgranular zone morphology(MP:0030981)

  • abnormal hippocampus morphology(MP:0000807)

  • abnormal hippocampus pyramidal cell layer(MP:0008284)
    • more 8 phenotypes
  • abnormal hippocampus pyramidal cell morphology(MP:0009940)

  • abnormal response to novelty(MP:0003107)

  • abnormal sucrose solution preference(MP:0020379)

  • abnormal synaptic bouton morphology(MP:0008571)

  • behavioral despair(MP:0002573)

  • decreased CNS synapse formation(MP:0004998)

  • increased hippocampus pyramidal cell length(MP:0012457)

  • nervous system phenotype(MP:0003631)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (Pgk promoter), E. coli neomycin-resistance gene, bovine growth hormone poly(A), mouse Klk8 genomic DNA
    Research applicationNeurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Neurosci., 17, 600-610 (2001).
    DepositorSadao Shiosaka (Nara Institute of Science and Technology)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data