Strain Data Sheet

RBRC02762

Strain Information

Image
BRC No.RBRC02762
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.B6CB-Psme1/Psme2<tm1Smta>
Former Common namePA28 alpha beta KO, C57BL/6-PA28ab-/-, B6.Cg-Psme1/Psme2<tm1Tchi>
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.
Murata S, Udono H, Tanahashi N, Hamada N, Watanabe K, Adachi K, Yamano T, Yui K, Kobayashi N, Kasahara M, Tanaka K, Chiba T
EMBO J., 20, 5898-5907 (2001). 11689430

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Psme1
MGI:1096367		proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)14Psme1<tm1Smta>
MGI:2388600		targeted mutation 1, Shigeo Murata
Psme2
MGI:1096365		proteasome (prosome, macropain) activator subunit 2 (PA28 beta)14Psme2<tm1Smta>
MGI:2388601		targeted mutation 1, Shigeo Murata
neo neomycin resistance gene (E. coli)14 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal tumor susceptibility(MP:0002166)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Psme1/Psme2 genomic DNA, Polyoma enhancer/herpes simplex virus thymidine kinase gene (MC1) promoter, E. coli Neomycin resistance gene
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J. 20, 5898-5907 (2001).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorShigeo Murata (Tokyo Metropolitan Institute of Medical Science)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data