Strain Data Sheet
RBRC02771
Strain Information | |
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| Image | |
| BRC No. | RBRC02771 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | C.B-17/Icr Prkdc<scid>-Tg(INS-TRECK/DTR)1Rin |
| Former Common name | BALB/c Prkdc<scid>-Tg(INS-TRECK/DTR)1Rin |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | C.B-17/Icr-scid/Jcl |
| Appearance | |
| Strain development | Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C.B-17/Icr-scid fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 ((scid background, the same line as the #70 in BBRC2013 article). |
| Strain description | scid-INS-TRECK Transgenic mice, having the diphtheria toxin receptor (hDTR) driven by the human insulin promoter and Prkdc<scid> mutation. Hyperglycemia was observed within 3 days after the administration of DT. |
| Colony maintenance | |
| References | Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury. Sekine M, Monkawa T, Morizane R, Matsuoka K, Taya C, Akita Y, Joh K, Itoh H, Hayashi M, Kikkawa Y, Kohno K, Suzuki A, Yonekawa H Transgenic Res., 21(1):51-62 (2011). 21431867Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout. Matsuoka K, Saito M, Shibata K, Sekine M, Shitara H, Taya C, Zhang X, Takahashi T A, Kohno K, Kikkawa Y, Yonekawa H Biochem. Biophys. Res. Commun., 436, 400-405 (2013). 23747725 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Prkdc MGI:104779 | protein kinase, DNA activated, catalytic polypeptide | 16 | Prkdc<scid> | severe combined immunodeficiency | |||
| HBEGF | heparin-binding EGF-like growth factor (human) | UN | HBEGF | human Insulin promoter | |||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | more 56 phenotypes |
| Detailed phenotype data |  |
Ordering Information | |
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| Donor DNA | Human Insulin promoter (SphI/BamHI) fragment, Rabbit Beta-globin intron, Human HB-EGF cDNA, Rabbit Beta-globin polyA/regulatory domain |
| Research application | Diabetes and Obesity Research Immunology and Inflammation Research covid19_progression |
| Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochem. Biophys. Res. Commun., 436, 400-405 (2013).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
| Depositor | Hiromichi Yonekawa (Tokyo Metropolitan Institute of Medical Science) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |