Strain Data Sheet

RBRC02775

Strain Information

Image
BRC No.RBRC02775
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC3.Cg-Prkdc<scid>/Nrs
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Prkdc
MGI:104779		protein kinase, DNA activated, catalytic polypeptide16Prkdc<scid> severe combined immune deficiency
  • severe combined immunodeficiency due to DNA-PKcs deficiency(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal NK cell physiology (MP:0010766)

  • abnormal Peyer's patch morphology (MP:0000696)

  • abnormal complement pathway (MP:0002471)

  • abnormal humoral immune response (MP:0001800)

  • abnormal intestinal epithelium morphology (MP:0000488)
    • more 54 phenotypes
  • abnormal level of surface class II molecules (MP:0005042)

  • abnormal lymph node B cell domain morphology (MP:0002344)

  • abnormal lymph node morphology (MP:0002339)

  • abnormal response to transplant (MP:0005671)

  • abnormal spleen white pulp morphology (MP:0002357)

  • abnormal thymus corticomedullary boundary morphology (MP:0009543)

  • abnormal thymus lobule morphology (MP:0002367)

  • abnormal thymus morphology (MP:0000703)

  • absent B cells (MP:0008071)

  • absent Peyer's patches (MP:0002831)

  • absent pre-B cells (MP:0000238)

  • absent thymus cortex (MP:0010250)

  • decreased B cell number (MP:0005017)

  • decreased B cell proliferation (MP:0005093)

  • decreased CD4-positive, alpha-beta T cell number (MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)

  • decreased IgG level (MP:0001805)

  • decreased NK cell number (MP:0008045)

  • decreased T cell number (MP:0005018)

  • decreased T cell proliferation (MP:0005095)

  • decreased bone marrow cell number (MP:0000333)

  • decreased erythrocyte cell number (MP:0002875)

  • decreased immunoglobulin level (MP:0002460)

  • decreased leukocyte cell number (MP:0000221)

  • decreased level of surface class I molecules (MP:0001841)

  • decreased lymphocyte cell number (MP:0005016)

  • decreased mature B cell number (MP:0008211)

  • decreased pre-B cell number (MP:0008209)

  • hematopoietic system phenotype (MP:0005397)

  • immune system phenotype (MP:0005387)

  • impaired complement classical pathway (MP:0002473)

  • impaired natural killer cell mediated cytotoxicity (MP:0005070)

  • increased NK cell number (MP:0008044)

  • increased T cell derived lymphoma incidence (MP:0002024)

  • increased cellular sensitivity to X-ray irradiation (MP:0002879)

  • increased circulating glucose level (MP:0005559)

  • increased eosinophil cell number (MP:0005011)

  • increased granulocyte number (MP:0000322)

  • increased length of allograft survival (MP:0004751)

  • increased macrophage cell number (MP:0005425)

  • increased mean corpuscular volume (MP:0002590)

  • increased monocyte cell number (MP:0000220)

  • increased neutrophil cell number (MP:0000219)

  • lymph node hypoplasia (MP:0008101)

  • lymphoid hypoplasia (MP:0002223)

  • muscle phenotype (MP:0005369)

  • premature death (MP:0002083)

  • salivary gland inflammation (MP:0001870)

  • small Peyer's patches (MP:0008135)

  • small lymphoid organs (MP:0000687)

  • small thymus (MP:0000706)

  • spleen hypoplasia (MP:0000694)

  • stomach inflammation (MP:0001873)

  • thymus cyst (MP:0014130)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorNational Institute of Radiological Sciences (National Institute of Radiological Sciences (NIRS))
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data