Strain Data Sheet

RBRC02818

Strain Information

Image
BRC No.RBRC02818
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Clnk<tm1Rygo>
Former Common name
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell C A, Kitamura D, Goitsuka R
Blood, 107, 3647-3655 (2006). 16439675

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Clnk
MGI:1351468		cytokine-dependent hematopoietic cell linker5Clnk<tm1Rygo>
MGI:3774508		targeted mutation 1, Ryo Goitsuka
GFP Green Fluorescent Protein (Aequorea victoria)5
loxP phage P1 loxP5loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal NK T cell physiology (MP:0008042)

  • abnormal interferon-gamma secretion (MP:0008559)

  • decreased interleukin-4 secretion (MP:0008700)

  • immune system phenotype (MP:0005387)

  • increased interferon-gamma secretion (MP:0008566)
    • more 1 phenotypes
  • increased natural killer cell mediated cytotoxicity (MP:0003080)
    • Detailed phenotype data

    Ordering Information

    Donor DNAJellyfish EGFP DNA (from pEGFP-C1), SV40 polyadenylation signal sequence (from pEGFP-C1), λ bacteriophage P1 Loxp sequence
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 107, 3647-3655 (2006).
    DepositorRyo Goitsuka (Tokyo University of Science)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data