Strain Data Sheet

RBRC02819

Strain Information

Image
BRC No.RBRC02819
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129P2-Clnk<tm1Rygo>
Former Common name
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Ryo Goitsuka, Tokyo University of Science.
Strain description
Colony maintenance
References
Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell C A, Kitamura D, Goitsuka R
Blood, 107, 3647-3655 (2006). 16439675

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Clnk
MGI:1351468
cytokine-dependent hematopoietic cell linker5Clnk<tm1Rygo>
MGI:3774508
targeted mutation 1, Ryo Goitsuka
GFP Green Fluorescent Protein (Aequorea victoria)5
neo neomycin resistance gene (E. coli)5 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal NK T cell physiology (MP:0008042)

  • abnormal interferon-gamma secretion (MP:0008559)

  • decreased interleukin-4 secretion (MP:0008700)

  • increased interferon-gamma secretion (MP:0008566)

  • increased natural killer cell mediated cytotoxicity (MP:0003080)
  • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neomycin resistance gene (from pEGFP-C1), Jellyfish EGFP DNA (from pEGFP-C1), Mouse PGK1 promoter (from pKSTK Neo Loxp), SV40 polyadenylation signal sequence (from pEGFP-C1), λ bacteriophage P1 Loxp sequence
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 107, 3647-3655 (2006).
    DepositorRyo Goitsuka (Tokyo University of Science)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data