Strain Data Sheet

RBRC02820

Strain Information

Image
BRC No.RBRC02820
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Gab1<tm1Nmoc>
Former Common nameGab1 conditional mouse
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain developmentDeveloped by Toshio Hirano, Osaka University in 2007.
Strain description
Colony maintenance
References
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.
Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh G Y, Kodama T, Hirota H, Otsu K, Hirano T, Mochizuki N
J. Clin. Invest., 117, 1771-1781 (2007). 17571162

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gab1
MGI:108088		growth factor receptor bound protein 2-associated protein 18Gab1<tm1Nmoc> targeted mutation 1, Naoki Mochizuki
  • autosomal recessive nonsyndromic hearing loss 26(MedGEN)
    • loxP phage P1 loxP8loxP
    loxP phage P1 loxP8loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAEnterobacteria phage P1 LoxP sites, mouse Gab1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Clin. Invest., 117, 1771-1781 (2007). The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECPIENT who wants to use the BIOLOGICAL RESOURCE for the purpose other than education and research in non-profit organization is requested to make a Material Transfer Agreement with Osaka University.
    DepositorToshio Hirano (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data