Strain Information | |
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Image | |
BRC No. | RBRC02830 |
Type | Transgene Congenic |
Species | Mus musculus |
Strain name | B6.B6C3-Tg(Th-SNCA*140m)01-1Yosh |
Former Common name | Syn140m-01-1, B6.Cg-Tg(Th-SNCA*)01-1Yosh |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Masaki Wakamatsu, Makoto Yoshimoto, Taisho Pharmaceutical Co., Ltd. in 2001. The transgene was injected into the pronuclei of B6C3F1 fertilized eggs. The mutant mice were backcrossed C57BL/6. |
Strain description | Th-SCNA transgenic mice expressing human alpha synuclein under the control of tyrosine hydroxylase promoter. Syn130m line (RBRC02829) having a human alpha synuclein sequence with an Ala53Thr point mutation and a lacking of 10 amino acids at the C-terminus, Syn140m line (RBRC02830) having a human alpa synuclein sequence with an Ala 53Thr point mutation. Syn130m line (RBRC02829) is useful as a model of Parkinson Disease. Syn130m Tg mice exhibit decreased dopamine level and dopaminergic neuron number. Motor activity and exploratory behavior are reduced compared to controls. Tg homozygous mice are postnatal lethal. Syn140m line (RBRC02830) is available as a control of Syn130m line. Syn140m Tg mice show no obvious abnormality. |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein. Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M J. Neurosci. Res., 85, 1819-1825 (2007) 17465029Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice. Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S, Kobayashi K, Iwatsubo T, Yoshimoto M Neurobiol. Aging, 29, 574-585 (2008) 17174013 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
SV40 polyA additional signal | UN | ||||||
HBB2 | rabbit beta-globin intron | UN | HBB2 | ||||
SNCA | synuclein, alpha (human) | UN | SNCA | rat tyrosine hydroxylase (TH) promoter |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human mutated α-synuclein cDNA (A53T), Rat Tyrosine hydroxylase promoter, Rabbit β-globin intron, SV40 polyA-additional signal |
Research application | Mouse Models for Human Disease |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci. Res., 85, 1819-1825 (2007). |
Depositor | Taisho Pharmaceutical Co.,Ltd. (Taisho Pharmaceutical Co., Ltd.) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Sci Rep 9(1) 7567(2019) 31110191 |