Strain Data Sheet

RBRC02891

Strain Information

Image
BRC No.RBRC02891
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Ovol2<tm1Iiu>
Former Common nameOvo12-KO, Movo-KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.
Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S
Genes Cells 12, 773-785 (2007). 17573777

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ovol2
MGI:1338039		ovo like zinc finger 22Ovol2<tm1Sito>
MGI:3777011		targeted mutation 1, Seiji Ito
  • posterior polymorphous corneal dystrophy 1(MedGEN)
    • loxP phage P1 loxP2loxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal angiogenesis (MP:0000260)

  • abnormal aortic sac morphology (MP:0012510)

  • abnormal blood circulation (MP:0002128)

  • abnormal embryonic tissue morphology (MP:0002085)

  • abnormal endocardium morphology (MP:0003974)
    • more 19 phenotypes
  • abnormal extraembryonic tissue morphology (MP:0002086)

  • abnormal heart development (MP:0000267)

  • abnormal heart looping (MP:0000269)

  • abnormal heart ventricle morphology (MP:0005294)

  • abnormal placenta vasculature (MP:0003231)

  • abnormal placental labyrinth vasculature morphology (MP:0008803)

  • abnormal vasculogenesis (MP:0001622)

  • abnormal vitelline vascular remodeling (MP:0004076)

  • abnormal vitelline vasculature morphology (MP:0003229)

  • absent intersomitic vessels (MP:0012254)

  • absent myocardial trabeculae (MP:0000293)

  • absent pharyngeal arches (MP:0003874)

  • absent vitelline blood vessels (MP:0001719)

  • decreased embryo size (MP:0001698)

  • embryonic growth retardation (MP:0003984)

  • embryonic lethality during organogenesis, complete penetrance (MP:0011098)

  • hemorrhage (MP:0001914)

  • open neural tube (MP:0000929)

  • small heart (MP:0002188)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Ovo12 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 12, 773-785 (2007).
    DepositorSeiji Ito (Kansai Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Jeyarajah MJ, Patterson VS, Jaju Bhattad G, Zhao L, Whitehead SN, Renaud SJ.
    Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development.
    Commun Biol 7(1) 1254(2024) 39363116