Strain Data Sheet

RBRC02946

Strain Information

Image
BRC No.RBRC02946
TypeInbred
SpeciesMus musculus
Strain nameNSY
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Masao Shibata, Nagoya University School of Medicine. The NSY mice were originated from Jcl:ICR with selective breeding for glucose intolerance.
Strain descriptionAnimal model of type 2 diabetes mellitus. Develop spontaneous non insulin dependent diabetes mellitus (NIDDM) with aging. Almost 100% in males and 20% in females exhibit diabetes mellitus at 48 weeks of age. NSY = Nagoya Shibata Yasuda.
Colony maintenanceSibling x Sibling
References
The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity.
Ueda H, Ikegami H, Yamato E, Fu J, Fukuda M, Shen G, Kawaguchi Y, Takekawa K, Fujioka Y, Fujisawa T, et a l
Diabetologia., 38, 503-508 (1995). 7489831

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal glucose tolerance(MP:0005291)

  • abnormal pancreatic beta cell morphology(MP:0005217)

  • decreased insulin secretion(MP:0003059)

  • hyperglycemia(MP:0001559)

  • increased body length(MP:0001257)
    • more 5 phenotypes
  • increased body mass index(MP:0006087)

  • increased body weight(MP:0001260)

  • increased circulating insulin level(MP:0002079)

  • increased epididymal fat pad weight(MP:0009288)

  • increased pancreas weight(MP:0009108)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Diabetologia., 38, 503-508 (1995). The RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University.
    DepositorHironori Ueda (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Co-creation Bureau, Osaka University HP

    BRC mice in Publications

    Takato T, Iwata K, Murakami C, Wada Y, Sakane F.
    Chronic administration of myristic acid improves hyperglycaemia in the Nagoya-Shibata-Yasuda mouse model of congenital type 2 diabetes.
    Diabetologia 60(10) 2076-2083(2017) 28707095