Strain Data Sheet

RBRC03001

Strain Information

Image
BRC No.RBRC03001
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CAG-INHBE)16Ohm
Former Common nameTgAct_E
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.
Hashimoto O, Ushiro Y, Sekiyama K, Yamaguchi O, Yoshioka K, Mutoh K, Hasegawa Y
Biochem. Biophys. Res. Commun., 341, 416-424 (2006). 16426570

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
INHBE human Inhibin beta E submitUNINHBE CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
loxP phage P1 loxPUNloxP
loxP phage P1 loxPUNloxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating amylase level(MP:0008804)

  • abnormal pancreatic acinus morphology(MP:0009145)

  • decreased circulating lipase level(MP:0011887)

  • decreased pancreatic acinar cell number(MP:0009149)

  • exocrine pancreas hyperplasia(MP:0003337)
    • more 2 phenotypes
  • pancreatic acinar hypoplasia(MP:0009154)

  • small pancreas(MP:0004247)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHuman Inhibin beta E submit cDNA, CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorOsamu Hashimoto (Kitasato University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data