Strain Data Sheet

RBRC03076

Strain Information

Image
BRC No.RBRC03076
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;129S-Apcs<tm1Smae>
Former Common nameApcs
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Serum amyloid P component enhances induction of murine amyloidosis.
Togashi S, Lim S K, Kawano H, Ito S, Ishihara T, Okada Y, Nakano S, Kinoshita T, Horie K, Episkopou V, Gottesman M E, Costantini F, Shimada K, Maeda S
Lab. Invest., Vol. 77, 525-531 (1997). 9389795

Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity.
Tamaoki T, Tezuka H, Okada Y, Ito S, Shimura H, Sakamoto M, Endo T, Ozaki Y, Kanba S, Maeda S
Nat. Med., Vol. 11, 11-12 (2005). 15635430

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Apcs
MGI:98229		amyloid P component, serum1Apcs<tm1Smae>
MGI:2388056		targeted mutation 1, Shuichiro Maeda
neo neomycin resistance gene (E. coli)1 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • amyloidosis(MP:0000604)

  • decreased susceptibility to endotoxin shock(MP:0008734)

  • increased autoantibody level(MP:0003725)

  • renal/urinary system phenotype(MP:0005367)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neomycin resistance gene, Mouse Apcs 遺伝子
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Lab. Invest., 77, 525-531 (1997).
    DepositorShuichiro Maeda (University of Yamanashi)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data